From the original post:
"Snakes On A Plane!" (this is based on the assumption that it's a title, a tagline, and a premise all in one. I like the idea of a poster that says "Snakes On A Plane: Snakes on a plane!")
"Hey, we could have gone with the other writer's idea: Muskrats in a Helicopter."
From the comments:
"aviophobic ophidiophobics welcome"
"No guns. No knives. Just fists, fangs, and 200 tons of aluminum."
"It's 'Snakes on a Line' Squared!"